Though I can understand how one might conceive that Hacking takes Dexterity. If it's anything like the programming class I took, you have to learn to type really fast with perfect accuracy, so having crazy-good manual dexterity seems like a great boon.
After the first playthrough (after I learned how kickass shotguns are), I always stocked up on ammunition from the local weapons vendor (or Fat Larry) before I did one of the storyline quests. The enemies you're fighting aren't always going to be dropping the kind of ammo you want (ex: the triform warghouls and headrunners in the Nossie sewers), and you might not have specialized in the weapons they do drop (firearms and/or long blades in the Society of Leopold Monastery). My first character was Gangrel, which means I stacked points into Unarmed whenever I got the chance. That was great for feeding on targets (a combat "clinch"/feed move requires high Unarmed), but there are a bunch of bosses where ranged + powerful knockback are the only way to go (like the Chang Bros.).
For the Chang Bros. specifically, once you enter the mausoleum and have the conversation, back up into the tunnel you came in through. You can stand there and blast 'em with a shotgun (12ga or SPAS) whenever they pop around the corner. You conserve ammo by only shooting when they're in the narrow confines and can't escape, and they usually teleport out after taking a good shot to the face. It might take a bit longer than running around and killing them in melee, but you take a LOT less damage and surprise attacks.
If you can manage it, I'd hold off doing the Hollywood zombie quest until after you've done the Hotel Hallowbrook, or wherever Wesp5 stashed the flamethrower. Crowd control + damage-over-time + reasonable ammo consumption if you're not just holding down the trigger. You can stretch that weapon out a looooooong(ish) time if you shoot in tiny bursts.